ITPKA DrugBank Gene Name P23677 UniProt Accession 3706 Entrez Gene Id Gene Info: Publications: Overington et al., 2006, How many drug targets are there?, Nat Rev Drug

Gene ID: Human(3706) Summary: Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling.

15q14-q21 is Genes. HSA: 3706(ITPKA) 100988859(ITPKA). GGO: 101142571(ITPKB) 115930848(ITPKA). PON CSAB: 103229987(ITPKB) 103245796(ITPKA). RRO Use the search box at the top right of all Ensembl views to search for a gene, phenotype, sequence Gene-based displays Gene: ITPKA ENSG00000137825. 24 May 2016 In silico analysis of The Cancer Genome Atlas data set was also performed.

Bcor-mutationer har hittats i AML [46], Itpka bidrar till differentiering av ytterligare fyra gener: ITPKA, SYNJ2, INPP5A och INPP4B var signifikant associerade med ESCC (P <0, 05); och fem ytterligare gener: ITPKC, ITPKB, INPPL1, ITPKA (Inositol-Trisphosphate 3-Kinase A) is a Protein Coding gene. Among its related pathways are superpathway of inositol phosphate compounds and Metabolism. Gene Ontology (GO) annotations related to this gene include calmodulin binding and calmodulin-dependent protein kinase activity. An important paralog of this gene is ITPKB.

The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. The Parkinson’s disease-associated gene ITPKB protects against α-synuclein aggregation by regulating ER-to-mitochondria calcium release Daniel J. Apiccoa,b,1 , In contrast, ITPKA is expressed primarily in neurons, while ITPKC expression is restricted to glia (27).

Inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) is the last identified member of the inositol 1,4,5-trisphosphate 3-kinases… Expand

1 RefSeq (NM) Transcript Type Coding Product Type Silencer® Select Availability. Made to Order.

Gene: ITPKA - ENSCAFG00000009562 - Canis lupus familiaris (dog) General information. Ensembl ID: ENSCAFG00000009562: Name: ITPKA: Description

Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. ITPKA. Gene … ITPKA Gene, Drug Resistance, Tissue Distribution, Mutation Distribution, Variants, ITPKA Genome Browser, ITPKA References. ITPKA - Explore an overview of ITPKA, with a histogram displaying coding mutations, full tabulated details of all associated variants, … The protein encoded by the ITPKB gene is one of 3 isoforms of Inositol-trisphosphate 3-kinase expressed in humans. Gene information about ENSG00000137825 / ITPKA - inositol-trisphosphate 3-kinase A Itpka MGI Mouse Gene Detail - MGI:1333822 - inositol 1,4,5-trisphosphate 3-kinase A. View mouse Itpka Chr2:119742337-119751253 with: phenotypes, sequences, polymorphisms, proteins, references, … GuideToPharmacology Gene Category Name: Inositol 1,4,5-trisphosphate 3-kinases: GuideToPharmacology Gene Category ID: 280: Gene Biotype: PROTEIN_CODING Inositol-1,4,5-trisphosphate-3-kinase-A (ITPKA) has recently been found to be implicated in the tumor progression of various cancers. However, the expression and the prognostic value of ITPKA in hepatocellular carcinoma (HCC) remains unexplored.

ITP3K proteins regulate inositol phosphate metabolism by phosphorylation of the second messenger inositol 1,4,5-trisphosphate to produce Ins (1,3,4,5)P 4, which is sometimes abbreviated as IP 4. Results: Inositol-trisphosphate 3-kinase A gene (ITPKA), a kinase with limited tissue distribution, was identified as a potential oncogene. We showed that ITPKA expression is up-regulated in many forms of cancers, including lung and breast cancers, and that overexpressed ITPKA contributes to tumorigenesis.
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Summary: Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Use SelfDecode to get personalized health recommendations based on your genes. Get started today with an existing DNA file or order a SelfDecode DNA kit!

dramatically down-regulated ITPKA expression in all OSCC cell lines examined.
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Plasmid pCNL-N1_ITPKA from Dr. Yasushi Okada's lab contains the insert inositol triphosphate 3-kinase A and is published in Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4352-6. doi: 10.1073/pnas.1418468112. Epub 2015 Mar 23. This plasmid is available through Addgene.

1 RefSeq (NM) Transcript Type Coding Product Type Silencer® Select Availability. Made to Order. Catalog # 4390771 Standard | 5 nmol Price (USD): 324.00. Your Price (USD): Online offer (USD): Check Figure 1.

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Despite recent advances in cancer therapy, the overall 5-year survival rate of patients with lung cancer remains low. The aim of our study was to sear…

Itpka inositol 1,4,5-trisphosphate 3-kinase A [ (house mouse)] Gene ID: 228550 , updated on 22-Nov-2020 Gene name: ITPKA (HGNC Symbol) Synonyms: IP3-3KA, IP3KA: Description: Inositol-trisphosphate 3-kinase A (HGNC Symbol) Chromosome: 15: Cytoband: q15.1: Chromosome location (bp) 41493393 - 41503551: Number of transcripts i Itpka - Inositol-trisphosphate 3-kinase A - Rattus norvegicus (Rat) - Itpka gene & protein UniProtKB - P17105 (IP3KA_RAT) ITPKA (inositol-trisphosphate 3-kinase A) Since ITPKA gene body methylation occurs early in tumor development, it could serve as biomarker for early detection of lung cancer. Detailed mechanistic studies revealed that down-regulation of ITPKA in lung adenocarcinoma cancers reduced both, tumor growth and metastasis. Biological context of ITPKA. Localization of the genes for human inositol 1,4,5-trisphosphate 3-kinase A (ITPKA) and B to chromosome regions 15q14-q21 and 1q41-q43, respectively, by in situ hybridization.

UCSC Genes ITPKA (uc001znz.3) at chr15:41786056-41795757 - Homo sapiens inositol-trisphosphate 3-kinase A (ITPKA), mRNA.

Get started today with an existing DNA file or order a SelfDecode DNA kit! UCSC Genes ITPKA (uc001znz.3) at chr15:41786056-41795757 - Homo sapiens inositol-trisphosphate 3-kinase A (ITPKA), mRNA. Symbol: Itpka: Name: inositol-trisphosphate 3-kinase A: RGD ID: 619950: Description: Exhibits Rac GTPase binding activity; calmodulin-dependent protein kinase activity; and inosit The ITPKC gene provides instructions for making one version (isoform) of the inositol 1,4,5-trisphosphate 3-kinase (ITPK) enzyme. This enzyme helps add a cluster of oxygen and phosphorus atoms (a phosphate group) to a molecule called Ins(1,4,5)P3 to produce a molecule called Ins(1,3,4,5)P4. Inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) is the last identified member of the inositol 1,4,5-trisphosphate 3-kinases… Expand Compare & Order ITPKA plasmids, CDNA clones, ORF clones and more genomics products.

Next-day shipping cDNA ORF clones derived from ITPKA inositol-trisphosphate 3-kinase A available at GenScript, starting from $99.00. Gene views which provide displays for data associated at the gene level such as orthologues, paralogues, regulatory regions and splice variants. This view is a gene level view. To access the transcript level displays select a Transcript ID in the table above and then navigate to the information you want using the menu at the left hand side of the page. dramatically down-regulated ITPKA expression in all OSCC cell lines examined. ITPKA protein encoded by the gene located on chromosome.